Genetically Encoded Polymers: Construction of Multifunctional Therapeutics without Sacrificing Homogeneity
2nd Special Joint Meeting with the Golden Gate Polymer Forum
Volker Schellenberger, President and CEO, Amunix Operating, Inc.
Date: Tuesday, June 13, 2017, 6 – 9 PM
Location: Michael’s at Shoreline Park Mountain View, CA 94043
For reservations, please click here.
Historically, pharmaceuticals had very simple designs. Most drugs would bind to a single receptor to turn in on, off, or to block binding of its natural ligand. Our rapidly expanding knowledge of human physiology at the molecular level allows us to dream of much more complex functions for a pharmaceutical. We may want it to interact with multiple receptors, differentiate between diseased and healthy tissues, or use certain physiological cues to turn its activity on or turn off. We now have the means to rapidly design binding domains that interact with receptors. Amunix has been working on protein polymers (called XTEN®) that allow us to assemble multiple such domains into a single molecule with precise control of spacing between domains. We can insert weak links that break upon certain physiological events (a bleeding event) or upon entering into a particular tissue (tumor, inflamed tissue) and we can modify the size of the pharmaceutical, which affects its ability to penetrate into various tissues. This seminar will describe the concept of protein polymers as well as our rapidly expanding toolbox that allows us to design increasingly complex molecules while maintaining perfect homogeneity.
Volker Schellenberger is President and CEO of Amunix Operating Inc, which he co-founded with Willem Pim Stemmer in 2006. He initially served as Amunix’s Chief Scientific Officer and is the lead inventor of the company’s XTEN technology. Volker has over 20 years of industry experience in protein engineering and drug discovery. Prior to co-founding Amunix he served as head of Genencor’s protein engineering department. Volker received his Ph.D. from Leipzig University (Germany) in 1986. After postdoctoral work at the Institute for Protein Research in Pushchino (Russia), the University of Göttingen, and with Bill Rutter at the University of California, San Francisco he joined Genencor in 1994. Volker is author of over 40 scientific papers and inventor of more than 70 issued or pending patent applications. He is a recipient of the Karl Lohmann prize of the German Society of Biochemists.
Register here for GGPF or ACS registrants.
|Seminar||Genetically Encoded Polymers – Construction of Multifunctional Therapeutics without Sacrificing Homogeneity|
|Date||Tuesday, June 13|
|Cost||Early registration (before Monday, June 5, 11:59 PM),
Employed or post-doc: $30
Students: $15Regular registration (after Monday, June 5, 11:59 PM),
Employed or post-doc: $35
Students: $20After registration deadline (Monday, June 12, 5:00 PM, if space available)
Employed or post-doc: $40
Students: $25Free if you attend just the lectures at 8:00 PM (but please let us know for headcount)
|Time||6:00 Social Hour
|Location||Michael’s at Shoreline Park Mountain View, CA|
|Meal options||Seafood – Broiled salmon with lemon beurre blanc
Chicken – Chicken Florentine
Vegetarian – Mushroom crepes